Testosterone

Testosterone is essential for maintaining muscle strength, bone density, stamina, libido, and
sexual function in both men and women. Testosterone levels decline with age in both sexes.
Women's levels are 20 times lower than men's, but testosterone is essential to their health and
quality of life too. Women's levels drop by 50% between the ages of 20 and 40. Many women in
their 40s and 50s are suffering from extremely low testosterone levels. A woman's testosterone
test result states that the "normal" range is 0-76ng/dL. So a physician practicing "reference
range endocrinology" will tell her that she's "normal" even if there is no detectable testosterone
in her blood! Optimal levels for most women are more like 50-65ng/dL.
Testosterone brings the
same benefits to women as it does to men, only on a smaller scale.


Men lose their testosterone gradually after age 25, causing fatigue, depression, decreased
strength, loss of libido, and mental slowing.
Because male andropause is gradual and is less
drastic than female menopause, men think that they are "just getting old", so they don't grasp
the hormone connection and the need for hormone replacement. In men, testosterone
restoration to high-normal levels improves muscle mass, strength, exercise tolerance, mood
and energy. Many studies show that
higher levels of testosterone within the reference range
protect against cardiovascular disease, diabetes, dementia, hypertension, abdominal obesity
and arthritis.
Nearly every study of testosterone and heart attacks shows that men with
lower levels of testosterone have higher risk.
Men with prostate cancer who are treated with
androgen deprivation therapy--where their testosterone level is lowered to that of a
woman--have been found to develop heart disease, diabetes, and metabolic syndrome. They
are at increased risk for death from heart disease.


The conventional population reference ranges cannot be used to diagnose testosterone
deficiency as levels decline with age, and the reported range includes almost all men in that
age group. Therefore the lower limits are far too low for both health and quality of life. For
instance, the lower limit for free testosterone for a middle-aged man is 5 pg/ml. The upper limit
for a young woman is 2 pg/ml. Compare this to the upper limit of 28 pg/ml for young men! The
evidence indicates that men require free testosterone levels of 20 pg/ml or better for optimal
health.


Contrary to popular opinion,
scientific studies show that higher levels of testosterone Do Not
cause prostate enlargement or prostate cancer
. Studies of men on testosterone
replacement have consistently shown there is no increased risk of prostate cancer.
In fact, the
evidence is clear:
It is LOW testosterone levels that increase the risk of prostate cancer!
(See the new book Testosterone for Life by Dr. Abraham Morgentaler.)  Contrary to popular
misconceptions, testosterone restoration does not cause aggression or anger. It makes men
more patient, more sociable, and less prone to anger. They feel more energetic and vital.

For men, Dr. Lindner prefers weekly testosterone cypionate or enanthate injections. These are
self-administered subcutaneously, not intramuscularly. The testosterone-containing creams
and gels are very difficult to monitor, produce an abnormal DHT/testosterone ratio, and produce
low estradiol levels in men. Estradiol is important for men--many of the benefits of testosterone
come from its conversion to estradiol. Dr. Lindner finds no evidence to support the belief that
estradiol levels must be minimized in men who are taking testosterone.


Here again, as with the female hormones, lay persons and most medical professionals still
think that the problems caused by artificial hormones substitutes also occur with natural,
physiological hormone restoration. "Roid rage" and liver disease are caused by oral
17-alkylated testosterone substitutes and other non-bioidentical anabolic steroids, usually
taken in doses that are many times greater than "replacement" doses. As with other hormones,
conventional medical opinion about testosterone is lagging way behind the scientific evidence.
In the near future it will become standard medical practice to restore youthful levels of this
essential and beneficial hormone to both men and women.
For Health and Quality of Life